ADVANCED MOLECULAR AND EXPERIMENTAL HEMATOLOGY

Acquisition of the basic knowledge necessary for the choice and use of omics for the diagnosis and attribution of the risk of progression of the main neoplastic hemopathies.

At the end of the course, students will be able to choose and develop the most suitable technological approach for understanding the pathophysiological basis of hematological neoplasms, with particular reference to multiple myeloma, non-Hodgkin's lymphomas and chronic lymphocytic leukemia.

Frontal lessons and laboratory

Basic knowledge of the HLA system, pathophysiology of chronic and neoplastic inflammation processes, anatomy of the immune system is suggested, molecular hematology.

After a general overview of the main omics technologies developed for understanding the main hematological neoplasms, the student will be introduced to the application of gene therapy, immunotherapy and metabolomics used for the development of precision medicine. At each lesson, the discussion of a scientific article will make it possible to critically highlight the experimental approach adopted for understanding the pathology of interest.

Manuale di malattie del Sangue, Elsevier di  Bosi, De Stefano, Di Raimondo, La Nasa

Hematology. Pathophysiology, diagnosis and treatment, Esculapio di  Pier Luigi Zinzani, Sante Tura, Michele Cavo

Ematologia Smart, Idelson Gnocchi di Fiorina Giona

Gene and Cell Therapy: Biology and Applications, Springer Link di Giridhara R. Jayandharan

Chimeric Antigen Receptor T-Cell Therapies for Cancer 1st Edition A Practical Guide, Elsevier di Daniel Lee Nirali N. Shah

ongoing written test and final thesis about one/more strategies to overcome cellular therapy resistance.