Vincenzo Giuseppe Nicoletti
- Since 2002 Nov. 1st, present position: Associate Professor in Biochemistry
- 1997/3/24, Assistant professor in Biochemistry (Faculty of Medicine).
- 1993-1994, Post-Doctoral fellow in Neurobiology.
- 1990-1992, Biennial fellowship, C.N.R. (National Italian Council of Research).
- 1988-1989, Research fellow at the Molecular Biology Department of the "Institute for Basic Research in developmental disabilities", Staten Island, New York (USA).
- 1987-1989 Ph.D. in Neurobiology, University of Catania (Italy). Institute of Biochemistry, Faculty of Medicine.
- 1985/Dec./20 Degree of Specialist in Marine Biochemistry (magna cum laude) University of Messina (Italy).
- 1985 qualification as Professional Biologist, University of Catania (Italy).
- 1983/11/22 Graduation (magna cum laude) in Biological Sciences University of Catania (Italy).
PUBLICATIONS
1. D.F. Condorelli, R. Avola, N. Belluardo, L. Insirello, V.G. Nicoletti, P. Carpano, M. Bindoni and A.M. Giuffrida-Stella. (1988). Astroglial response to injury of hippocampal neurons. Senile Dementias II International Symposium Eds. (A. Agnoli, J. Cahn, N. Lassen, R. Mayeux) John Libbey Eurotext, Paris. pp. 27-39.
2. D.F. Condorelli, R. Avola, N. Ragusa, L. Insirello, V.G. Nicoletti, P. Carpano, N. Belluardo, M. Bindoni and A.M. Giuffrida-Stella. (1988). Astrocyte mitogenic factors from rat hippocampus after toxin induced neuronal degeneration. It. J. Biochem. 38: 118A-121A. (IF 0.379)
3. D.F. Condorelli,.N Belluardo, R. Avola, L. Insirello, P. Carpano, V. Nicoletti, M. Bindoni and A.M. Giuffrida-Stella. (1989). Effect of trophic factors, released after hippocampal injury, on astroglial cell proliferation. Metabolic Brain Disease 4: 41-46. (IF 1.029)
4. D.F. Condorelli, V. Nicoletti, P. Carpano, L. Insirello, R. Avola and A.M. Giuffrida-Stella. (1990). Epidermal growth factor treatment during early postnatal development: glutamine synthetase and glutamate decarboxilase activities in mouse brain. Int. J. Dev. Neurosci. 8: 1-8. (IF 1.557)
5. V. Spina-Purrello, R. Avola, D.F. Condorelli, V. Nicoletti, L. Insirello, S. Reale, A. Costa, N. Ragusa and A.M. Giuffrida-Stella. (1990). ADP-ribosylation of proteins in brain regions of rats during postnatal development. Int. J. Dev. Neurosci. 8: 167-174. (IF 1.557)
6. D. Soifer, V. Nicoletti, K. Cabane, K. Mack, and B. Poulos. (1991). Expression of the Neurofilament Protein NF-H in L-cells. J. Neurosci. Res. 30: 63-71. (IF 3.637)
7. R. Avola, P. Carpano, F. Ingrao, G. Magrì, L. Insirello, V.G. Nicoletti, D.F. Condorelli, N. Ragusa, and A.M. Giuffrida-Stella. (1991). Epidermal growth factor stimulates the proliferation of cerebellar immature astrocytes, maintained under different culture conditions. It. J. Biochem. 40: 79A-82A. (IF 0.379)
8. Avola R., Magrì G., Ingrao F., Insirello L., Carpano P., Nicoletti V.G., Condorelli D.F., Ragusa N., and Giuffrida Stella A.M. (1991). Effect of EGF on DNA labeling in rat cerebellar immature astrocytes, maintained under different culture conditions: presence or absence of polylysine and/or serum. Annals of the New York Academy of Sciences, 633: 540-542. (IF 1.030)
9. Nicoletti V. G. and D. F. Condorelli (1992). Optimized PEG-method for rapid purification of high-quality plasmid DNA: high yield from "midi-prep". BioTechniques, 14: 532, 536. (IF 2.251)
10. Nicoletti V.G., Condorelli D.F., Dell'Albani P., Bonanno G., Giuffrida Stella AM (1992). Expression and structure of the rat GFAP gene. It. J. Biochem. 41, 366A-368A. (IF 0.379)
11. Nicoletti V.G., Dell'Albani P., Condorelli D.F., Giuffrida Stella A.M. (1994). Glutamate receptor expression during aging in rat brain. It. J. Biochem., 43: 43A. (IF 0.379)
12. Nicoletti V.G., Barresi V., Caruso A., Conticello S., Condorelli D.F., Giuffrida Stella A.M. (1994). Methylation status and tissue-specific expression of the rat GFAP gene. It. J. Biochem., vol 43, N° 5, 247A 249A. (IF 0.379)
13. Condorelli D.F., Nicoletti V.G., Barresi V., Caruso A., Conticello S., de Vellis J.*, Giuffrida Stella A.M. (1994). Tissue-specific DNA Methylation Patterns of the Rat Glial Fibrillary Acidic Protein Gene. Journal of Neuroscience Research, 39: 694-707. (IF 3.637)
14. Nicoletti V.G., Condorelli D.F., Dell'Albani P., Ragusa N., Giuffrida Stella A.M. (1995). a-amino-3-hydroxy-5-methylisoxazolepropionate-selective glutamate receptor subunits in rat hippocampus during aging. Journal of Neuroscience Research 40: 220-224. (IF 3.377)
15. V. G. Nicoletti, E. A. Tendi, C. Lalicata, S. Reale, A. Costa, R. F. Villa, N. Ragusa, and A. M. Giuffrida Stella (1995) Changes of mitochondrial cytochrome c oxidase and FoF1 ATP synthase subunits in rat cerebral cortex during aging. Neurochem. Res. vol. 20, 1465-1470. (IF 1.577)
16. Nicoletti V. G., Tendi E. A., Lalicata C., Reale S., Costa A., Villa R. F. , Guerrieri F., Ragusa N. , and Giuffrida Stella A. M. (1995) Modifications of mitochondrial cytochrome c oxidase and FoF1 ATP synthase subunits content in rat cerebral cortex during aging. It. J. Biochem. vol. 44, 329A-331A. (IF 0.379)
17. Nicoletti V. G., Tendi E. A., Lalicata C., Reale S., Costa A., Villa R.F., Ragusa N., and Giuffrida Stella A. M. (1996) Age-related changes of mitochondrial cytochrome c oxidase and FoF1 ATP synthase subunit contents in rat cerebral cortex. Arch. Gerontol.Geriatr., Suppl.5, 509-514. (IF 0.779)
18. Nicoletti V. G., Tendi E. A., Console A., Privitera A., Ragusa N., and Giuffrida Stella A. M. (1996) Gene expression of cytochrome c oxidase and FoF1-ATPase subunits in rat brain during aging. It. J. Biochem. vol. 45, 176. (IF 0.379)
19. Condorelli D.F., Dell'Albani P., Conticello S., Barresi V., Nicoletti V.G., Caruso A., Kahn M., Vacanti M., Albanese V., de Vellis J., Giuffrida Stella A.M. (1997) A neural-specific demethylated domain in the distal promoter of the glial fibrillary acidic protein gene. Developmental Neuroscience 19: 446-456. (IF 1.596)
20. Nicoletti V. G., Tendi E. A., Console A., Privitera A., Villa R.F., Ragusa N., and Giuffrida Stella A. M. (1998) Regulation of cytochrome c oxidase and FoF1-ATPase subunits expression in rat brain during aging. Neurochem. Res. vol. 23, 55-61. (IF 1.677)
21. Nicoletti V.G., Caruso A., Tendi E.A., Privitera A., Console A., Calabrese V., Spadaro F., Ravagna A., Copani A. and Giuffrida Stella A.M.* (1998) Effect of NO synthase induction in mixed cortical and astroglial cell cultures on the expression of mitochondrial respiratory chain enzyme subunits. Biochimie 80, 871-881. (IF 1.617)
22. Condorelli D.F., Nicoletti V.G., Barresi V., Conticello S.G., Caruso A., Tendi E.A., Giuffrida Stella A.M. (1999) Structural features of the rat GFAP gene and identification of a novel alternative transcript. Journal of Neuroscience Research. Vol. 56(3):219-28. (IF 2.874)
23. Condorelli D.F., Nicoletti V.G., Dell'Albani P., Barresi V., Caruso A., Conticello S.G., Belluardo N., Giuffrida Stella A.M. (1999) GFAP mRNA expression in the normal rat brain and after brain injury. Neurochem. Res., 24 (5), 709-714. (IF 1.677)
24. Calabrese V., Copani A., Testa D., Ravagna A., Spadaro F., Tendi E., Nicoletti V.G. and Giuffrida Stella A.M. (2000) Nitric oxide synthase induction in astroglial cell cultures: effect on Heat shock protein 70 synthesis and oxidant/antioxidant balance. Journal of Neuroscience Research. 60: 613-622. (IF 2.874)
25. Dell’Albani P., Santangelo R., Torrisi L., Nicoletti V.G., de Vellis J. and Giuffrida Stella A.M. (2001) JAK/STAT signaling pathway mediates cytokine induced iNOS expression in primary astroglial cell cultures. Journal of Neuroscience Research. 65: 417-424. (IF 2.874)
26. Nicoletti VG, Meli GA, Marino VM, Copani A, Giuffrida-Stella AM (2001) NMDA-induced neuroprotection in cerebellar granule cells: correlation with mitochondrial respiratory enzyme expression. Mitochondrion 1 (Suppl. 1) S70.
27. V.G. Nicoletti, V. Spina-Purrello, D. Patti, R. Santangelo and A.M. Giuffrida Stella. (2001) Dual role of PARP expression after iNOS induction in astroglial cell: proapoptotic or rescuing. J. Neurochem. 77 (suppl. 1): 47.
28. Dell’Albani P., Santangelo R., Torrisi L., Nicoletti V.G., Albanese V., De Vellis J. and Giuffrida-Stella A.M. (2001) Inducible nitric oxide sinthase expression in astroglial cells: role of JAK2 and STAT1α/β. J. Neurochem. 78 (suppl. 1): 149.
29. Nicoletti VG, Nicoletti R, Ferrara N, Meli G, Reibaldi M, Reibaldi A. (2003) Diabetic patients and retinal proliferation: an evaluation of the role of vascular endothelial growth factor (VEGF). Exp. Clin. Endocrinol. Diabetes. 111: 209-14.
30. Nicoletti VG and Giuffrida Stella AM (2003) Role of PARP under Stress Conditions: Cell Death or Protection? Neurochemical Research. 28: 187–194. IF 1.763
31. Dell'Albani P, Santangelo R, Torrisi L, Nicoletti VG, Giuffrida Stella AM. (2003) Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS. Neurochem Res. 28: 53-64. IF 1.763
32. C. Cuppari, V. Spina-Purrello, D. Patti, D. Licciardello, P. Perticone, A.M. Giuffrida-Stella, V.G. Nicoletti. (2004) Aβ25-35 toxicity in primary astroglial cell cultures is correlated with status of aggregation. The Italian Journal of Biochemistry vol. 53 n.3:275.
33. Nicoletti V. G., Marino V. M., Cuppari C., Licciardello D., Patti D., Spina Purrello V., and A. M. Giuffrida Stella (2005) Effect of Antioxidant Diets on Mitochondrial Gene Expression in Rat Brain During Aging Neurochem. Res. 30: 737–752. IF 2,187
34. Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E. (2007) Trehalose effects on alpha-crystallin aggregates. Biochem. Biophys. Res. Commun. 354(4):899-905. (Epub 2007 Jan 22). IF 2,749
35. Nicoletti V. G., Santoro A. M., Grasso G., Vagliasindi L. I., Giuffrida M. L., Cuppari C., Spina Purrello V., Giuffrida Stella A., Rizzarelli E. (2007) Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection. Journal of Neuroscience Research, 85:2239-2245. IF 3,268
36. V. Spina-Purrello, D. Patti, A. M. Giuffrida-Stella, V. G. Nicoletti (2008) PARP and cell death or protection in rat primary astroglial cell cultures under LPS/IFNγ induced proinflammatory conditions. Neurochem Res. 33:2583-92. IF 2,187
37. Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E. (2009) Protective Effects of L- and D-Carnosine on alpha-Crystallin Amyloid Fibril Formation: Implications for Cataract Disease. Biochemistry. 48: 6522–6531. IF 3,379
38. Vittoria Spina-Purrello, Salvatrice Giliberto, Vincenza Barresi, Vincenzo G. Nicoletti, Anna Maria Giuffrida Stella, Enrico Rizzarelli (2010) Modulation of PARP-1 and PARP-2 Expression by L-carnosine and Trehalose After LPS and INFγ-Induced Oxidative Stress. Neurochem Res 35:2144–2153. IF1,576.
39. Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E. (2011). The inorganic perspective of Nerve Growth Factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of Nerve Growth Factor encompassing the recognition domain of the TrkA receptor. CHEMISTRY - A EUROPEAN JOURNAL Mar 21;17(13):3726-38. doi: 10.1002/chem.201002294. Epub 2011 Feb 25. IF 5,382
40. Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E. (2012) The inorganic perspectives of neurotrophins and Alzheimer's disease. J Inorg Biochem. 111:130-7. doi: 10.1016/j.jinorgbio.2011.10.017. Epub 2011 Dec 1. IF 3.197
41. Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E. (2012) Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives. Chemistry 18(49):15618-31. doi: 10.1002/chem.201202775. Epub 2012 Nov 7.
42. Chillemi R, Greco V, Nicoletti VG, Sciuto S. (2013) Oligonucleotides conjugated to natural lipids: synthesis of phosphatidyl-anchored antisense oligonucleotides. Bioconjug Chem. 24(4):648-57. doi: 10.1021/bc300602g. Epub 2013 Mar 15.
43. Travaglia A, La Mendola D, Magrì A, Pietropaolo A, Nicoletti VG, Grasso G, Malgieri G, Fattorusso R, Isernia C, Rizzarelli E. (2013) Zinc(II) interactions with brain-derived neurotrophic factor N-terminal peptide fragments: inorganic features and biological perspectives. Inorg Chem. 52(19):11075-83. doi: 10.1021/ic401318t. Epub 2013 Sep 26. IF 4.794
44. Sinopoli A, Magrì A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, Grasso G. (2014) The role of copper(II) in the aggregation of human amylin. Metallomics. 2014 6(10):1841-52. doi: 10.1039/c4mt00130c. Epub 2014 Aug 1. IF 3.585
45. Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E. (2015) Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity. J Inorg Biochem. 142:39-46. doi: 10.1016/j.jinorgbio.2014.09.008. Epub 2014 Sep 28. IF 3.205
46. Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E. (2015) A small linear peptide encompassing the NGF N-terminus partly mimics the biological activities of the entire neurotrophin in PC12 cells. ACS Chem Neurosci. 6(8):1379-92. doi: 10.1021/acschemneuro.5b00069. Epub 2015 May 15. IF 4.348
47. Kornblatt AP, Nicoletti VG, Travaglia A. (2016) The neglected role of copper ions in wound healing. J Inorg Biochem. 161:1-8. doi: 10.1016/j.jinorgbio. 2016.02.012. Epub 2016 Feb 11. IF 3.348
48. Naletova I, Nicoletti VG, Milardi D, Pietropaolo A, Grasso G. (2016) Copper, differently from zinc, affects the conformation, oligomerization state and activity of bradykinin. Metallomics. 8:750-761, ISSN: 1756-591X, doi: 10.1039/c6mt00067c. IF 3.975
49. Magrì A, La Mendola D, Nicoletti VG, Pappalardo G, Rizzarelli E. (2016) New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity. Chemistry, a European Journal. 5;22(37):13287-300. doi: 10.1002/chem.201602816. Epub 2016 Aug 5. IF 5.317
50. Magrì A, Tabbì G, Giuffrida A, Pappalardo G, Satriano C, Naletova I, Nicoletti VG, Attanasio F. (2016) Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties. J Inorg Biochem. 164:59-69. doi: 10.1016/j.jinorgbio.2016.08.013. Epub 2016 Aug 27. IF 3.348
51. Pandini G, Satriano C, Pietropaolo A, Gianì F, Travaglia A, La Mendola D, Nicoletti VG, Rizzarelli E. (2016) The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor. Front Neurosci. 10:569. doi: 10.3389/fnins.2016.00569. eCollection 2016. IF 3.566
52. Caruso G, Distefano DA, Parlascino P, Fresta CG, Lazzarino G, Lunte SM, Nicoletti V.G. (2017). Receptor-mediated toxicity of human amylin fragment aggregated by short and long-term incubations with copper ions. MOLECULAR AND CELLULAR BIOCHEMISTRY, 425:85-93, ISSN: 0300-8177, doi: 10.1007/s11010-016-2864-1. IF 4.069
53. Naletova I, Satriano C, Curci A, Margiotta N, Natile G, Arena G, La Mendola D, Nicoletti VG, Rizzarelli E. (2018) Cytotoxic phenanthroline derivatives alter metallostasis and redox homeostasis in neuroblastoma cells. Oncotarget. 9(91):36289-36316. doi: 10.18632/oncotarget.26346. IF 5.312 ???
54. Bellia F, Lanza V, García-Viñuales S, Ahmed IMM, Pietropaolo A, Iacobucci C, Malgieri G, D'Abrosca G, Fattorusso R, Nicoletti VG, Sbardella D, Tundo GR, Coletta M, Pirone L, Pedone E, Calcagno D, Grasso G, Milardi D. (2019) Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways. Chem Sci. 10(9):2732-2742. doi: 10.1039/c8sc03394c. IF 9,556
55. Naletova I, Satriano C, Pietropaolo A, Gianì F, Pandini G, Triaca V, Amadoro G, Latina V, Calissano P, Travaglia A, Nicoletti VG, La Mendola D, Rizzarelli E. (2019) The Copper(II)-Assisted Connection between NGF and BDNF by Means of Nerve Growth Factor-Mimicking Short Peptides. Cells. 8(4). pii: E301. doi: 10.3390/cells8040301. IF 5.656
56. Santoro AM, Lanza V, Bellia F, Sbardella D, Tundo GR, Cannizzo A, Grasso G, Arizzi M, Nicoletti VG, Alcaro S, Costa G, Pietropaolo A, Malgieri G, D'Abrosca G, Fattorusso R, García-Viñuales S, Ahmed IMM, Coletta M, Milardi D. Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity. ChemMedChem. 2020 Feb 5;15(3):302-316. doi: 10.1002/cmdc.201900612. Epub 2019 Dec 17. PMID: 31797568. IF 3.5
57. Nicoletti VG, Pajer K, Calcagno D, Pajenda G, Nógrádi A. The Role of Metals in the Neuroregenerative Action of BDNF, GDNF, NGF and Other Neurotrophic Factors. Biomolecules. 2022 Jul 22;12(8):1015. doi: 10.3390/biom12081015. PMID: 35892326; PMCID: PMC9330237. IF 4.8
58. Nicoletti VG, Fisicaro F, Aguglia E, Bella R, Calcagno D, Cantone M, Concerto C, Ferri R, Mineo L, Pennisi G, Ricceri R, Rodolico A, Saitta G, Torrisi G, Lanza G, Pennisi M. Challenging the Pleiotropic Effects of Repetitive Transcranial Magnetic Stimulation in Geriatric Depression: A Multimodal Case Series Study. Biomedicines. 2023 Mar 21;11(3):958. doi: 10.3390/biomedicines11030958. PMID: 36979937; PMCID: PMC10046045. IF 4.5
59. Cambria D, Longhitano L, La Spina E, Giallongo S, Orlando L, Giuffrida R, Tibullo D, Fontana P, Barbagallo I, Nicoletti VG, Volti GL, Fabro VD, Coda ARD, Liso A, Palumbo GA. IGFBP-6 Alters Mesenchymal Stromal Cell Phenotype Driving Dasatinib Resistance in Chronic Myeloid Leukemia. Life (Basel). 2023 Jan 17;13(2):259. doi: 10.3390/life13020259. PMID: 36836615; PMCID: PMC9960877. IF 3.4
Le linee di ricerca, condotte grazie alla partecipazione a vari progetti di ricerca nazionali ed internazionali, interessano studi principalmente nell’ambito della neurochimica e neurobiologia, negli ultimi anni affrontati su modelli in coltura cellulare. Particolare attenzione è stata ed è rivolta ai meccanismi molecolari dei processi di invecchiamento e delle patologie ad essi correlate (neurodegenerazione, tumore) attraverso classici approcci biochimici e biologico molecolari. Le alterazioni conformazionali proteiche, le disfunzioni mitocondriali, la disomeostasi del rame, le modificazioni dell’espressione di varie proteine chiave, la valutazione degli effetti neuroprotettivi di alcuni peptidi bioattivi (o altre molecole) disegnati ad hoc e infine lo studio di specifiche vie di trasduzione del segnale cellulare, rappresentano l’oggetto più comune degli studi effettuati ed attualmente in corso.