VEICOLAZIONE E DIREZIONAMENTO DEI FARMACI CON POLIMERI DI INTERESSE FARMACEUTICOModule VEICOLAZIONE E DIREZIONAMENTO DEI FARMACI
Academic Year 2022/2023 - Teacher: LUCIA MONTENEGROExpected Learning Outcomes
The aim of this course is to provide the student with knowledge and expertise about the strategies exploited in the field of drug-modified release and targeting and their use in biotechnology. In addition, the course focuses on fundamentals of biopharmaceutics and their application to pharmaceutical technology to provide the student with a comprehensive understanding of controlled drug delivery systems.
Course Structure
Frontal lessons. Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.
Required Prerequisites
Detailed Course Content
Administration routes and bioavailability of drugs. Controlled drug delivery systems: classification. Active and passive drug targeting. Fundamentals of controlled drug delivery systems: reservoir systems, osmotic systems, matrix systems, ion exchange systems.
Vesicular controlled delivery systems. Liposomes: advantages and limits, classification, preparation methods, physico-chemical and technological characterization, use in the pharmaceutical field. Ethosomes, transferosomes, niosomes. Technological properties and use in the pharmaceutical field.
Microparticles as controlled delivery systems: advantages and limits. Preparation and characterization methods. Use in the pharmaceutical field.
Nanoparticles as controlled delivery systems: polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers. Advantages and limits. Physico-chemical and technological characterization. Preparation methods. Use in the pharmaceutical field.
Chemically controlled delivery systems: prodrugs. Advantages and limits, properties and use in the pharmaceutical field.
Molecular inclusion complexes: cyclodextrins. Definition and classification. Preparation methods of cyclodextrin-drug inclusion complexes. Instrumental analyses to characterize inclusion complexes. Use in the pharmaceutical field.
Transdermal delivery systems: advantages and limits, technological properties, use in the pharmaceutical field.
Gene therapy: fundamentals and goals. Biological barriers to gene delivery. DNA and the oligonucleotide delivery: viral and synthetic carriers (liposomes, cationic polymers and lipopolyplexes).
Textbook Information
-COLOMBO P., CATELLANI P.L., GAZZANIGA A., MENEGATTI E., VIDALE E.; Principi di tecnologie Farmaceutiche; Casa Ed. Ambrosiana, Ultima Edizione.
-FLORENCE A.T. AND ATTWOOD D.; Le basi chimico-fisiche della Tecnologia Farmaceutica; Edises, Ultima Edizione.
- AULTON M.E. AND TAYLOR K.M. Tecnologie farmaceutiche. Progettazione e allestimento dei medicinali; Edra, Ultima Edizione
Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | Vie di somministrazione e biodisponibilità dei farmaci. | 2 |
| 2 | Forme farmaceutiche a rilascio modificato | 1, 2, 3 |
| 3 | Sistemi a rilascio modificato vescicolari | 1, 3 |
| 4 | Sistemi a rilascio modificato microparticellari | 1 |
| 5 | Sistemi a rilascio modificato nanoparticellari | 3 |
| 6 | Sistemi di inclusione molecolare: ciclodestrine | 3 |
| 7 | Sistemi transdermici | 1 |
Learning Assessment
Learning Assessment Procedures
Learning assessment is performed in the form of written test consisting of 5 open questions. Learning assessment may also be carried out on line, should the conditions require it.