MICROBIOLOGIA FARMACEUTICA, BIOTECNOLOGIE MICROBICHE FARMACEUTICHE E PRINCIPI DI IGIENEModule MICROBIOLOGIA FARMACEUTICA E BIOTECNOLOGIE MICROBICHE FARMACEUTICHE
Academic Year 2022/2023 - Teacher: Pio Maria FURNERIExpected Learning Outcomes
Know the principles of pharmaceutical production and pharmacopoeia; know the principles of quality control in microbiology; know the ISO and UNI EN procedures;
Know the principles of bio-safety;
Know the principles of microbial ecology that regulate the dynamics of populations in natural environments and their relationship with amensalistic symbiosis;
Know the main metabolic pathways and those of the secondary metabolism;
Know the vaccine production techniques (live, killed, recombinant, DNA and RNA);
Know the applications of microbial ghosts such as cargo systems and DDS;
Know the metabolic pathways that lead to the production of post biotics and the related engineering procedures.
Course Structure
Frontal oral presentation. Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus
Information for students with disabilities and / or SLD: To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the teaching objectives and specifications needs. It is also possible to contact the CInAP contact person (Center for Active and Participatory Integration - Services for Disabilities and / or SLD) of the department.
Required Prerequisites
Attendance of Lessons
Detailed Course Content
1) Dynamics of microbial populations in natural environments and the various forms of symbiosis
a) The dynamics within populations
b) The dynamics between microbial populations
c) Microbial consortia
2) The foundations of industrial microbiology
a) Isolation and screening of secondary metabolites and enzymes
i) Old and new approaches for the isolation of microorganisms from natural habitats
(1) Selective and non-selective systems
b) Fermentation and cell cultures
c) Genetics, genetic improvement of strains, recombinant proteins: examples
d) Genetic engineering of secondary metabolites: examples
e) Industrial applications of enzymes, biocatalysis, and evolution of enzymes: examples
f) Microbial fuels (biofuels): examples
g) Biological engineering and scale-up of industrial processes: examples
3) The pathways of primary and secondary metabolism
a) The classical metabolic pathways
b) Secondary metabolism
4) The principles of pharmaceutical production and pharmacopoeia
a) Quality control in pharmaceutical production and GLP and GMP procedures
b) Biosecurity
i) Law Decree 81/2008 and its amendments: microbiological risk
ii) Risks and Dangers: definitions
c) Vaccine production techniques (live, killed, recombinant, DNA and RNA);
5) Microbial “ghosts” such as cargo systems and DDS
a) Bacterial membrane vesicles and bacteriosomes
b) Viral-like particles and virosomes
c) Preparation and applications
6) Post-biotic
a) Probiotics and post biotics
b) Definition
c) Applications and perspectives
Textbook Information
Course Planning
Subjects | Text References | |
---|---|---|
1 | Dynamics of microbial populations in natural environments and the various forms of symbiosis | See studium |
2 | The fundamentals of industrial microbiology | See studium |
3 | The pathways of primary and secondary metabolism | See studium |
4 | The principles of pharmaceutical production and pharmacopoeia | See studium |
5 | Microbial “ghosts” such as cargo systems and / or DDS | See studium |
6 | Post-biotics | See studium |
Learning Assessment
Learning Assessment Procedures
The student who does not pass the exam will be able to go to the next session
Verification of learning can also be carried out electronically, should the conditions require it