PHARMACOLOGY AND PATHOPHYSIOLOGICAL OPTICSModule FARMACOLOGIA
Academic Year 2022/2023 - Teacher: CLAUDIO BUCOLOExpected Learning Outcomes
Provide the student with the basics of pharmacology and toxicology necessary for the performance of the role of optometrist
Intermediate targets:
• Know what medications are and the role they have in the therapeutic
• Understand the ways through which drugs modify the state of health of the patient
• Understand the factors that can alter the response to a drug
• Know the risks associated with the use of drugs
• Know the general principles of pharmacotherapy
• Know the toxicological and pharmacological profiles of the main ophthalmic drugs
Course Structure
Part I
Pharmacokinetics
Pharmacodynamics
Part II
• Drugs used in the field of ophthalmology
Detailed Course Content
Part I
Pharmacokinetics
- The student at the end of the course will be able to describe:
• the main routes of drug administration and for each describe the main features, advantages, disadvantages and contraindications
• processes of drug distribution in the body
• main processes of drug biotransformation
• major routes of elimination of drugs
• factors that can alter the elimination of drugs and the clinical consequences and therapeutic
• Describe the main pharmacokinetic parameters
• Principles of pediatric pharmacology and geriatric
Pharmacodynamics:
- The student at the end of the course will be able to describe:
• Receptors and drug-receptor interaction
• Receptor Agonists and Antagonists
• Signal transduction
• Desensitization and tachyphylaxis
-Cholinergic and adrenergic transmission
Part II
• Drugs for glaucoma
• Drugs for AMD: anti-VEGF
• Drugs for ocular pain
• Mydriatics and miotics
• Antibiotics used in ophthalmology
• Anti-inflammatory drugs
• Local anesthetics
• Lacrimal substitutes and viscoelastic substances
Textbook Information
Clarck et al. Pharmacology. Lippincott
Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | *principali vie di somministrazione dei farmaci e descrivere per ciascuna le caratteristiche principali, i vantaggi, gli svantaggi e le controindicazioni | Clarck et al. Le basi della Farmacologia Ed Zanichelli Cap. 1 |
| 2 | *processi di distribuzione, biotrasformazione ed eliminazione dei farmaci nell’organismo | Clarck et al. Le basi della Farmacologia Ed Zanichelli Cap1 |
| 3 | *fattori che possono alterare l’eliminazione dei farmaci e le conseguenze clinico-terapeutiche | Clarck et al. Le basi della Farmacologia Ed Zanichelli Cap. 1 |
| 4 | *Principali parametri farmacocinetici | Clarck et al. Le basi della Farmacologia Ed Zanichelli Cap. 1 |
| 5 | *Classificazione dei recettori, interazione farmaco-recettore e traduzione del segnale | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 2 e 3 |
| 6 | *Agonisti e antagonisti recettoriali | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 2 |
| 7 | *Tolleranza e tachifilassi | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 2 |
| 8 | *rasmissione colinergica | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 4 e 5 |
| 9 | *Trasmissione adrenergica | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 6 e 7 |
| 10 | *Mediatori chimici | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 3 a 42 |
| 11 | *Indice terapeutico, DE50, DT50 | clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 2 |
| 12 | * Aspetti farmacocinetici oculari | dispese/slides |
| 13 | *Farmaci per il glaucoma | Dispense/slides |
| 14 | *Farmaci per le affezioni vascolari retiniche | Dispense/slides |
| 15 | *Antibiotici | Clarck et al. ''Le Basi della Farmacologia'' Ed. |
| 16 | *Farmaci della pupilla | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli |
| 17 | Anestetici locali | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli |
| 18 | *Antinfiammatori | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 41 |
| 19 | *Farmaci per il dolore | Clarck et al. ''Le Basi della Farmacologia'' Ed. Zanichelli Cap 14 e 41 |
| 20 | *Sostituti lacrimali, sostanze viscolealstiche | dispense/slides |