APPROACHES TO GASTROINTESTINAL HEALTH
Module SCIENCE AND TECHNIQUES OF LABORATORY MEDICIN

Academic Year 2025/2026 - Teacher: LUCA FALZONE

Expected Learning Outcomes

The student must have developed and matured the theoretical, scientific and professional knowledge to understand the main methodologies for the analysis and identification of biomarkers associated with dysmetabolic disorders or linked to the metabolism of micro- and macronutrients. There are specific areas of expertise in which the student must acquire knowledge of the molecular methodologies used in the diagnosis of food intolerances, metabolic disorders and tumors potentially connected to incorrect diet or alcohol consumption. Finally, the student must have acquired skills in the critical processing of scientific data present in the literature and be able to search the main public databases for relevant information relating to biomarkers related to nutrition.


Taking into account the Dublin descriptors, the expected learning outcomes are therefore:

1. Knowledge and understanding: Upon completion of the course, students will have acquired theoretical, scientific, and professional knowledge related to the methodologies for analyzing and identifying biomarkers associated with metabolic disorders and the metabolism of micronutrients and macronutrients. They will be familiar with the main molecular methods used in the diagnosis of food intolerances, metabolic disorders, and cancers related to nutritional factors and alcohol consumption, understanding their principles and applications.

2. Ability to apply knowledge and understanding: Students will be able to apply their acquired knowledge to the interpretation of data derived from the analysis of nutritional and metabolic biomarkers. They will be able to use and evaluate the main molecular diagnostic methodologies in relation to various pathological conditions, correlating analytical results with metabolic and nutritional alterations.

3. Independent judgment: Students will have developed critical skills in evaluating scientific data related to nutritional and metabolic biomarkers, recognizing the reliability of results, methodological limitations, and potential sources of error. They will also be able to critically analyze and interpret relevant scientific literature.

4. Communication skills: Students will be able to clearly and appropriately communicate information and results related to biomarker analysis and diagnostic methodologies, using appropriate scientific terminology. They will be able to present and discuss data and interpretations with both specialists and non-specialists.

5. Learning skills: Students will have developed independent learning skills that will allow them to continuously update their knowledge in the field of nutritional and metabolic biomarkers. They will also be able to independently conduct searches in major scientific databases, selecting and critically applying the most relevant information.

Course Structure

The teaching activity will be frontal and supplemented by some seminars. For the training of the student, additional informative material (scientific articles of relevance) will be distributed.

Required Prerequisites

Prerequisites according to the study plan.

Attendance of Lessons

As established by the study course plan

Detailed Course Content

1. Brief overview of Nutrigenetics and Nutrigenomics

2. Main polymorphisms associated with metabolic disorders

3. Epigenetic regulation mechanisms mediated by micro- and macronutrients

4. Brief overview of techniques and methodologies used to perform genomic and epigenomic investigations

5. Role of the microbiota and interaction with micro- and macronutrients

6. Identification of biomarkers associated with specific nutrients or metabolic diseases

7. Nutrition and tumors

Textbook Information

There are no specific books. Supplementary teaching materials will be provided during the lessons.

Course Planning

 SubjectsText References
1Brief overview of Nutrigenetics and Nutrigenomicssupplementary teaching materials
2Main polymorphisms associated with metabolic disorderssupplementary teaching materials
3Epigenetic regulation mechanisms mediated by micro- and macronutrientssupplementary teaching materials
4Brief overview of techniques and methodologies used to perform genomic and epigenomic investigationssupplementary teaching materials
5Role of the microbiota and interaction with micro- and macronutrientssupplementary teaching materials
6Identification of biomarkers associated with specific nutrients or metabolic diseasessupplementary teaching materials
7Nutrition and tumorssupplementary teaching materials

Learning Assessment

Learning Assessment Procedures

The student's preparation will be assessed through a multiple choice written test and possibly integrated with an oral exam

Examples of frequently asked questions and / or exercises

What is meant by epigenetics?

What is the best definition of microRNAs?

Why is obesity considered a risk factor for the development of breast cancer?

What is the static test that allows you to establish the diagnostic sensitivity and specificity of a biomarker?

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