PHARMACOLOGY OF BIOTECHNOLOGICAL PRODUCTS

Academic Year 2022/2023 - Teacher: Mariangela CHISARI

Expected Learning Outcomes

Students will learn the fundamental mechanisms that regulate the mechanism of action of biological drugs, their pharmacokinetics and studies for their authorization process to market. Also, students will learn about techniques used for the development of biotechnological products and clinical applications of some classes of these drugs. Students will learn how to approach to scientific experiments and how interpret results.

Course Structure

Traditional classes. Students are invited to actively participate with questions and comments on discussed topics.

Required Prerequisites

Basic knowledge in the following topics: Anatomy, Histology, Biochemistry, Physiology, Pathology

Attendance of Lessons

Mandatory attendance to classes, except for new instructions for contingent reasons

Detailed Course Content

Identification of molecular targets for biological drugs (b. d.)

B. d. production

B.d. Pharmacokinetics

Preclinical and clinical drug development

Biosimilar drugs

B. d. used for glucose metabolism

B. d. for hematopoiesis and hemostasis

B. d. used in cancer therapy

Vaccines

Experimental procedures

How to obtain and validate scientific data

Data interpretation from scientific articles

Textbook Information

Rossi F., Cuomo V., Riccardi, C, "Farmacologia. Principi di base e applicazioni terapeutiche", Minerva Medica.
Goodman e Gilman: "Le basi Farmacologiche della terapia. il Manuale" ed italiana; McGraw-Hill.

Course Planning

	Subjects	Text References
1	Identification of molecular targets for biological drugs (b. d.)	see textbook tab
2	B. d. production	see textbook tab
3	B.d. Pharmacokinetics	see textbook tab
4	Preclinical and clinical drug development	see textbook tab
5	Biosimilar drugs	see textbook tab
6	B. d. used for glucose metabolism	see textbook tab
7	B. d. for hematopoiesis and hemostasis	see textbook tab
8	B. d. used in cancer therapy	see textbook tab
9	Vaccines	see textbook tab
10	Experimental procedures	see textbook tab
11	How to obtain and validate scientific data	see textbook tab
12	Data interpretation from scientific articles	see textbook tab

Learning Assessment

Learning Assessment Procedures

Oral exam about topics listed in the program and discussed during classes. The final evaluation will be determined by appropriate use of the scientific language, the ability to explain what has been learned, as well as by the skills of critical thinking.

Examples of frequently asked questions and / or exercises

Receptor: types and functions, drug elimination, side effects and adverse reactions of bevacizumab, VEGF inhibitors

VERSIONE IN ITALIANO

Corso di laurea magistrale in

Biotecnologie mediche