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Dottorato di ricerca in

Neuroscienze

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Presentazione del dottorato

Coordinatore: Claudio Bucolo
Durata: 3 anni

Descrizione e obiettivi del corso

Il curriculum di Neuropsicofarmacologia e Farmacologia Oculare fornisce competenze per lo studio dell’interazione farmaco-recettore, in silico, in vitro e in vivo, nonché per lo studio dei meccanismi molecolari e cellulari di neurotrasmissione e neuromodulazione, modulabili farmacologicamente per la terapia.

Il curriculum di Neurofisiologia studia la funzione nervosa, dai processi molecolari a quelli cellulari, dalle reti neurali fino al comportamento e ai correlati neuropsicologici. Essa comprende lo studio dei sistemi sensoriali, dell’attività motoria, del learning e memory, dei processi attentivi, delle emozioni e dei sistemi integrati e di metodologie diagnostico-funzionali della cognitività.

Il curriculum di Neuroscienze pre-cliniche e cliniche studia le patologie neurologiche con un approccio traslazionale definito from bench to bed, ovvero dal laboratorio alla clinica. Include protocolli di ricerca clinica-epidemiologica, meta-analisi, stesura di linee-guida, diagnostica strumentale, ricerca biologica e genetica, anche applicabili in neurochirurgia, e protocolli di analisi di immagini con tecnologie avanzate.

Il curriculum di Scienze Farmaceutiche comprende, da un lato la medicinal chemistry applicata alle terapie delle patologie del SNC, dall’altro la progettazione e la caratterizzazione di sistemi tecnologici innovativi (drug delivery systems) per la somministrazione e rilascio controllato di farmaci a livello del sistema nervoso centrale o della retina.

The PhD program in Neurosciences covers 4 main research lines or curricula.
  1. neuropsychopharmacology and ocular pharmacology,
  2. neurophysiology,
  3. preclinical and clinical neurosciences
  4. pharmaceutical neurosciences (medicinal chemistry and development of advanced drug delivery systems)
Each PhD student is supervised by one or more tutors that continuously monitor the work of PhD students during the realization of his/her PhD project.
Particularly, as regards as the neuropsychopharmacology and ocular pharmacology curriculum, the PhD students will study the molecular and cellular mechanisms of new molecules and/or drugs, also through a drug repurposing approach.
As regards as the neurophysiology research line, the PhD students will study nervous function, unveiling molecular and cellular mechanisms, including advanced approaches focused on link between neural networks and behavior or neuropsychological and pathological endpoints. The training will also cover the study of sensory systems (such as the visual system), motor activity, learning and memory, attention, employing diagnostic-functional methodologies of normal and pathological cognition.
Regarding the preclinical and clinical Neuroscience curriculum, the PhD students will use an integrated (from bench to bad) approach, to study psychiatric and neurological disorders, studying biomarker evaluation, epigenetic or genetic aspects of the disease, and correlation with clinical approaches: including neurosurgery, neurodiagnostic, neuropsychological tests, epidemiology, use of AI to neuroimaging analysis.
As regards as the pharmaceutical curriculum, PhD students will be trained to carry out drug design approaches or to develop innovative drug delivery system for controlled drug release to central nervous system or retina.
Main career opportunities of this doctoral career, besides the academia, include positions at pharmaceutical industries, public and private research institutions, drug regulatory agencies, pharmaceutical contract research organizations, or national health system networking.
 

 

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