EMATOLOGIA MOLECOLARE E SPERIMENTALE

Acquisition of the basic knowledge necessary for the choice and use of pre-clinical animal models of neoplastic haemopathies. Acquisition of the basic knowledge necessary for the understanding and application of the technologies necessary for the in vitro and ex vivo manipulation of human lymphocytes for the generation of TILs and CAR-T.

At the end of the course, students will be able to choose and develop the most suitable preclinical model for understanding the pathophysiological basis of haematological neoplasms, with particular reference to pathologies currently considered incurable (multiple myeloma and acute myeloid leukemia).

After a general overview of the mechanisms that regulate normal and pathological hematopoiesis, the student will be introduced to the definition and pathophysiology of the main diseases affecting red blood cells, white blood cells and platelets. A special attention will be paid to the most common forms of anemia and the most frequent hematological neoplasms. Priority will be given to the notions providing a general framework of the hematological patient and the current prospects for cure or control of the disease, with a special mention for the most modern therapeutic strategies used in hematology, including the basics of cellular therapy and bone marrow transplantation.  

Attendance is highly recommended due to the interactive nature of the lessons.