Massimo Caruso

1.    Lemus R, Lee KM, Emma R, Caruso M, Wood DM. Editorial: Application of new approach methodologies in toxicological assessment of next-generation tobacco and nicotine products. Front Toxicol. 2026 May 15;8:1843194. doi: 10.3389/ftox.2026.1843194. PMID: 42221360; PMCID: PMC13218689.

2.    Lopalco G, Carota G, Musso N, Di Pietro L, Privitera A, Bonacci PG, Buccarello L, Natuzzi D, Bizzoca R, Del Vescovo S, Caruso M, Caraci F, Vitale A, Venerito V, Iannone F, Caruso G. PPAR-γ dysregulation links NF-κB activation and Nrf2-driven antioxidant responses in axial spondyloarthritis: A pilot study. J Autoimmun. 2026 Apr 23;161:103557. doi: 10.1016/j.jaut.2026.103557. PMID: 42030776.

3.    Emma R, Carota G, Partsinevelos K, Rust S, Sun A, Giordano A, Volarevic V, Lesmana R, Goenawan H, Barliana MI, Arsenijevic A, Kastratovic N, Spasic B, Giardina C, Cantali M, Pittalà A, Saab MW, Amorini AM, Polosa R, Caruso M*, Li Volti G. Effect of electronic cigarette aerosols on cisplatin resistance in head and neck cancer cells: a collaborative replication study. BMC Cancer. 2026 Apr 22. doi: 10.1186/s12885-026-16029-8. Epub ahead of print. PMID: 42021215. *Corresponding author

4.    Emma R, Sun A, Partsinevelos K, Rust S, Volarevic V, Lesmana R, Giordano A, Goenawan H, Barliana MI, Arsenijevic A, Kastratovic N, Markovic V, Spasic B, Distefano A, Orlando L, Carota G, Polosa R, Caruso M*, Li Volti G. Toxicological Evaluation of Vanillin Flavor in E-Liquid Aerosols on Endothelial Cell Function: Findings from the Replica Project. Cardiovasc Toxicol. 2026 Apr 13;26(4):42. doi: 10.1007/s12012-026-10111-0. PMID: 41968178; PMCID: PMC13070984. *Corresponding author

5.    Emma R, Distefano A, Zuccarello P, Copat C, Ferrante M, Oliveri Conti GM, Pulvirenti R, Carota G, Campagna D, Polosa R, Rust S, Caruso M*, Li Volti G. Mechanistic toxicity profiling of nicotine-rich e-liquids: mitochondrial and oxidative stress responses in ALI-exposed bronchial cells. Mol Cell Biochem. 2026 Feb;481(2):899-910. doi: 10.1007/s11010-025-05430-9. Epub 2025 Nov 19. PMID: 41254430; PMCID: PMC12963075. *Corresponding author

6.    Cucco A, Pearce N, Simpson A, Pembrey L, Mpairwe H, Figueiredo CA, Cooper PJ, Douwes J, Brooks C, Adcock IM, Kermani NZ, Roberts GDM, Murray CS, Custovic A, Fontanella S; WASP Study Group; STELAR/UNICORN Consortium; U-BIOPRED Consortium*. Exploring geographic differences in IgE response through network and manifold analyses. J Allergy Clin Immunol. 2026 Jan;157(1):262-272. doi: 10.1016/j.jaci.2025.05.032. Epub 2025 Jun 30. PMID: 40602688. *part of the U-BIOPRED Consortium

7.    Giallongo S., Bellia F., Russo A., Fallico M., Polosa R., Castellino N., Longo A., Emma R., Partsinevelos K., Caruso M., Kartasasmita A.S., Sferrazzo G., Barbagallo I.A., Caltabiano R., Broggi G., Alanazi A.M., Volti G.L. Comparative Evaluation of Cigarette Smoke and a Heated Tobacco Product on Corneal Oxidative Stress in an Air/Liquid Interface Model. Investigative Ophthalmology and Visual Science, (2025), 66 (4). DOI: 10.1167/iovs.66.4.4

8.    Furnari S., Emma R., Caruso M., Furneri P.M., Fuochi V. Evaluating the Risks of Heated Tobacco Products: Toxicological Effects on Two Selected Respiratory Bacteria and Human Lung Cells. (2025) Toxics, 13 (2), art. no. 70. DOI: 10.3390/toxics13020070

9.    Meys R, Franssen FME, Van 't Hul AJ, Bakke PS, Caruso M, Dahlén B, Fowler SJ, Geiser T, Howarth PH, Horváth I, Krug N, Behndig AF, Singer F, Musial J, Shaw DE, Montuschi P, Zee AHM, Sterk PJ, Roberts G, Kermani NZ, Incalzi RA, Louis R, Andersson LI, Wagers SS, Dahlén SE, Chung KF, Adcock IM, Spruit MA. Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED. Health Qual Life Outcomes. 2024 Dec 20;22(1):109. doi: 10.1186/s12955-024-02321-3. PubMed PMID: 39707320; PubMed Central PMCID: PMC11662558.

10. Zounemat Kermani N, Chung KF, Macis G, Santini G, Clemeno FAA, Versi A, Sun K, Abdel-Aziz MI, Andersson LI, Auffray C, Badi Y, Bakke P, Brightling C, Brinkman P, Caruso M, Chanez P, De Meulder B, Djukanovic R, Fabbri L, Fowler SJ, Horvath I, Howarth P, James AJ, Kolmert J, Kraft M, Li CX, Maitland-van der Zee AH, Malerba M, Papi A, Rabe K, Sanak M, Shaw DE, Singh D, Sparreman Mikus M, van Den Berge M, Wheelock AM, Wheelock CE, Yasinska V, Guo YK, Wagers S, Barnes PJ, Bush A, Sterk PJ, Dahlen SE, Adcock IM, Siddiqui S, Montuschi P. Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics. Eur Respir J. 2024 Nov;64(5). doi: 10.1183/13993003.00207-2024. Print 2024 Nov. PubMed PMID: 39401856; PubMed Central PMCID: PMC11579543.

11. Distefano A, Orlando L, Partsinevelos K, Longhitano L, Emma R, Caruso M, Vicario N, Denaro S, Sun A, Giordano A, Tomasello B, Alanazi AM, Li Volti G, Amorini AM. Comparative evaluation of cigarette smoke and a heated tobacco product on microglial toxicity, oxidative stress and inflammatory response. J Transl Med. 2024 Sep 30;22(1):876. doi: 10.1186/s12967-024-05688-5. PubMed PMID: 39350202; PubMed Central PMCID: PMC11440907.

12. Distefano A, Orlando L, Giallongo S, Tropea E, Spampinato M, Santisi A, Longhitano L, Parisi G, Leonardi S, Russo A, Caruso M, Di Rosa M, Tibullo D, Salamone M, Li Volti G, Barbagallo IA. Fish Oil Containing Pro-Resolving Mediators Enhances the Antioxidant System and Ameliorates LPS-Induced Inflammation in Human Bronchial Epithelial Cells. Pharmaceuticals (Basel). 2024 Aug 14;17(8). doi: 10.3390/ph17081066. PubMed PMID: 39204170; PubMed Central PMCID: PMC11360764.

13. Emma R, Fuochi V, Distefano A, Partsinevelos K, Rust S, Zadjali F, Al Tobi M, Zadjali R, Alharthi Z, Pulvirenti R, Furneri PM, Polosa R, Sun A, Caruso M*, Li Volti G; Replica Project Group. Cytotoxicity, mutagenicity and genotoxicity of electronic cigarettes emission aerosols compared to cigarette smoke: the REPLICA project. Sci Rep. 2023 Oct 30;13(1):17859. doi: 10.1038/s41598-023-44626-1. PMID: 37903810; PMCID: PMC10616076. *Corresponding author

14. Caruso M, Emma R, Distefano A, Rust S, Poulas K, Giordano A, Volarevic V, Mesiakaris K, Boffo S, Arsenijevic A, Karanasios G, Pulvirenti R, Ilic A, Canciello A, Zuccarello P, Ferrante M, Polosa R, Li Volti G. Comparative assessment of electronic nicotine delivery systems aerosol and cigarette smoke on endothelial cell migration: the Replica Project. Drug Test Anal. 2023, 15(10). doi: 10.1002/dta.3349. pp.1164-1174. PMID: 35877466.

15. Versi A, Ivan FX, Abdel-Aziz MI, Bates S, Riley J, Baribaud F, Kermani NZ, Montuschi P, Dahlen SE, Djukanovic R, Sterk P, Maitland-Van Der Zee AH, Chotirmall SH, Howarth P, Adcock IM, Chung KF; U-BIOPRED consortium*. Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation. Allergy. 2023 Nov;78(11):2906-2920. doi: 10.1111/all.15776. Epub 2023 Jun 7. PMID: 37287344. *Part of the U-BIOPRED Consortium

16. Yasinska V., Gómez C., Kolmert J., Ericsson M., Pohanka A., James A., Andersson L.I., Sparreman-Mikus M., Sousa A.R., Riley J.H., Bates S., Bakke P.S., Kermani N.Z., Caruso M., Chanez P., Fowler S.J., Geiser T., Howarth P.H., Horváth I., Krug N., Montuschi P., Sanak M., Behndig A., Shaw D.E., Knowles R.G., Dahlén B., van der Zee A.-H.M., Sterk P.J., Djukanovic R., Adcock I.M., Chung K.F., Wheelock C.E., Dahlén S.-E., Jonsson E.W. Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids. (2023) ERJ Open Research, 9 (5), art. no. 00269-2023, DOI: 10.1183/23120541.00269-2023

17. Pavlovic D., Miloradovic D., Stojanovic M.D., Harrell C.R., Polosa R., Rust S., Volti G.L., Caruso M., Jakovljevic V., Djonov V., Volarevic V. Cigarette smoke attenuates mesenchymal stem cell-based suppression of immune cell-driven acute liver failure. (2023) Toxicology Letters, 385, pp. 12 – 20. DOI: 10.1016/j.toxlet.2023.08.006

18. Abdel-Aziz M.I., Thorsen J., Hashimoto S., Vijverberg S.J.H., Neerincx A.H., Brinkman P., Van Aalderen W., Stokholm J., Rasmussen M.A., Roggenbuck-Wedemeye M., Vissing N.H., Mortensen M.S., Brejnrod A.D., Fleming L.J., Murray C.S., Fowler S.J., Frey U., Bush A., Singer F., Hedlin G., Nordlund B., Shaw D.E., Chung K.F., Adcock I.M., Djukanovic R., Auffray C., Bansal A.T., Sousa A.R., Wagers S.S., Chawes B.L., Bønnelykke K., Sørensen S.J., Kraneveld A.D., Sterk P.J., Roberts G., Bisgaard H., Maitland-Van Der Zee A.H., Kolmert J., James A., Sousa A.R., Riley J.H., Bates S., Bakke P.S., Caruso M., Chanez P., Fowler S.J., Geiser T., Howarth P., Horvath I., Krug N., Montuschi P., Sanak M., Behndig A., Shaw D.E., Knowles R.G., Holweg C.T.J., Wheelock A.M., Dahlen B., Alving K., Chung K.F., Dahlen S.-E., Wheelock C.E., Andersson L., De Meulder B., Lutter R., Mumby S., Roberts G., Uddin M., Wagers S.S., Kermani N.Z. Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk. (2023) American Journal of Respiratory and Critical Care Medicine, 208 (2), pp. 142 – 154. DOI: 10.1164/rccm.202211-2107OC

19. Hou, R., Ye, G., Cheng, X., Shaw, D.E., Bakke, P.S., Caruso, M., Dahlen, B., Dahlen, S.-E., Fowler, S.J., Horváth, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandström, T., Auffray, C., De Meulder, B., Sousa, A.R., Adcock, I.M., Fan Chung, K., Sterk, P.J., Skipp, P.J., Schofield, J., Djukanović, R. The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts. (2023) Brain, Behavior, and Immunity, 111, pp. 249-258. DOI: 10.1016/j.bbi.2023.04.011

20. Fuochi, V., Floresta, G., Emma, R., Patamia, V., Caruso, M., Zagni, C., Ronchi, F., Ronchi, C., Drago,
F., Rescifina, A., Furneri, P.M. Heparan Sulfate and Enoxaparin Interact at the Interface of the Spike Protein of HCoV-229E but Not with HCoV-OC43. (2023) Viruses, 15 (3), art. no. 663. DOI: 10.3390/v15030663

21. Brandsma, J., Schofield, J.P.R., Yang, X., Strazzeri, F., Barber, C., Goss, V.M., Koster, G., Bakke, P.S., Caruso, M., Chanez, P., Dahlén, S.-E., Fowler, S.J., Horváth, I., Krug, N., Montuschi, P., Sanak, M., Sandström, T., Shaw, D.E., Chung, K.F., Singer, F., Fleming, L.J., Adcock, I.M., Pandis, I., Bansal, A.T., Corfield, J., Sousa, A.R., Sterk, P.J., Sánchez-García, R.J., Skipp, P.J., Postle, A.D., Djukanović, R., the U-BIOPRED Study Group. Stratification of asthma by lipidomic profiling of induced sputum supernatant. (2023) Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2023.02.032 

22. Caponnetto, P., Campagna, D., Maglia, M., Benfatto, F., Emma, R., Caruso, M., Caci, G., Busà, B.,
Pennisi, A., Ceracchi, M., Migliore, M., Signorelli, M. Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial (2023) JMIR Public Health and Surveillance, 9, art. no. e42628. DOI: 10.2196/42628

23. Longhitano L, Vicario N, Forte S, Giallongo C, Broggi G, Caltabiano R, Barbagallo GMV, Altieri R, Raciti G, Di Rosa M, Caruso M, Parenti R, Liso A, Busi F, Lolicato M, Mione MC, Li Volti G, Tibullo D. Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. Cancer Immunol Immunother. 2023 Jan;72(1):1-20. doi: 10.1007/s00262-022-03215-3. Epub 2022 Jun 3. Erratum in: Cancer Immunol Immunother. 2022 Jul 12;: PMID: 35654889; PMCID: PMC9813126.

24. Emma R^*, Caruso M^*, Campagna D, Pulvirenti R, Li Volti G. The Impact of Tobacco Cigarettes, Vaping Products and Tobacco Heating Products on Oxidative Stress. Antioxidants (Basel). 2022 Sep 16;11(9):1829. doi: 10.3390/antiox11091829. PMID: 36139904; PMCID: PMC9495690.*Co-first author

25. Brandsma J, Schofield JPR, Yang X, Strazzeri F, Barber C, Goss VM, Koster G, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Adcock IM, Pandis I, Bansal AT, Corfield J, Sousa AR, Sterk PJ, Sánchez-García RJ, Skipp PJ, Postle AD, Djukanović R; U-BIOPRED Study Group. Stratification of asthma by lipidomic profiling of induced sputum supernatant. J Allergy Clin Immunol. 2023 Mar 12:S0091-6749(23)00293-2. doi: 10.1016/j.jaci.2023.02.032. Epub ahead of print. PMID: 36918039.

26. Hoda U, Pavlidis S, Bansal AT, Takahashi K, Hu S, Ng Kee Kwong F, Rossios C, Sun K, Bhavsar P, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Krug N, Sandstrom T, Shaw DE, Lutter R, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Dahlen SE, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; U-BIOPRED study group. Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort. Clin Transl Med. 2022 Apr;12(4):e816. doi: 10.1002/ctm2.816. PMID: 35474304; PMCID: PMC9043117.

27. Maglia M, Quattropani MC, Polosa R, Panassidi A, Caruso M, Mangione M, Nicolosi V, Mazzeppi SD, Lenzo V, Sardella A, Caponnetto P. Qualitative study on the perception of combustible cigarettes, e-cigarettes and heated tobacco cigarettes among pregnant women. J Addict Dis. 2023 Mar 9:1-11. doi: 10.1080/10550887.2023.2184302. Epub ahead of print. PMID: 36892131.

28. Hajat, C., Stein, E., Selya, A., Polosa, R., Alaimo, S., Anfuso, C.D., Barbagallo, I., Basile, F., Battiato, S., Benhamou, B., Bertino, G., Bianchi, A., Biondi, A.G., Brandi, M.L., Cacciola, E., Cacciola, R.R., Cacopardo, B.S., Calogero, A.E., Cambria, M.T., Campagna, D., Caraci, F., Cariola, A., Caruso, M., Caponnetto, P., Ciancio, A., Cibella, F., Mauro, M., Piazza, J., Stefano, A., Drago, F., Failla, S., Faraci, R., Ferlito, S., Ferrante, M., Ferro, A., Ferro, G.A., Frasca, F., Frittitta, L., Furneri, P.M., Gagliano, A., Gallo, G., Galvano, F., Grasso, G., Guarino, F., Gulino, A., Jannini, E.A., Vignera, S.L., Lazzarino, G., Ledda, C., Leonardi, R.M., Volti, G.L., Longo, A., Lupo, G., Malerba, M., Marletta, L., Nicolosi, G., Nocera, F., Conti, G.O., Palazzo, G., Parenti, R., Pedullà, E., Pulvirenti, A., Purrello, F., Rapisarda, F., Rapisarda, V., Rizzo, R., Ronsisvalle, S., Ronsisvalle, G., Ruggieri, M., Santagati, M.C., Satriano, C., Sciacca, L., Signorelli, M.S., Tatullo, M., Tibullo, D., Tomaselli, V., Volarevic, V., Zanoli, L., Zappalà, A., The CoEHAR study group. Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research. (2022) Internal and Emergency Medicine, 17 (3), pp. 887-909. DOI: 10.1007/s11739-022-02967-1 

29. Tiotiu, A., Badi, Y., Kermani, N.Z., Sanak, M., Kolmert, J., Wheelock, C.E., Hansbro, P.M., Dahlén,
S.-E., Sterk, P.J., Djukanovic, R., Guo, Y., Mumby, S., Adcock, I.M., Chung, K.F., Hoda, U., Rossios,
C., Bel, E., Rao, N., Myles, D., Compton, C., Van Geest, M., Howarth, P., Roberts, G., Lefaudeux, D.,
De Meulder, B., Bansal, A.T., Knowles, R., Erzen, D., Wagers, S., Krug, N., Higenbottam, T.,
Matthews, J., Erpenbeek, V., Carayannopoulos, L., Roberts, A., Supple, D., deBoer, P., Caruso, M., Chanez, P., Horváth, I., Musial, J., Sandström, T., U-BIOPRED Consortium Project Team
Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma (2022) American Journal of Respiratory and Critical Care Medicine, 205 (4), pp. 397-411. DOI: 10.1164/rccm.202102-0355OC 

30. Alba A, Villaggio G, Messina GML, Caruso M, Federico C, Cambria MT, Marletta G, Sinatra F. Cytostatic Effects of Polyethyleneimine Surfaces on the Mesenchymal Stromal Cell Cycle. Polymers (Basel). 2022 Jun 29;14(13):2643. doi: 10.3390/polym14132643. PMID: 35808689; PMCID: PMC9269326.

31. Caruso, M., Emma, R., Distefano, A. Rust S, Poulas K, Zadjali F, Giordano A, Volarevic V, Mesiakaris K, Al Tobi M, Boffo S, Arsenijevic A, Zuccarello P, Ferrante M, Polosa R, Li Volti G and the Replica Project Group. Electronic nicotine delivery systems exhibit reduced bronchial epithelial cells toxicity compared to cigarette: the Replica Project. Sci Rep 11, 24182 (2021). https://doi.org/10.1038/s41598-021-03310-y

32. Abdel-Aziz MI, Vijverberg SJH, Neerincx AH, Brinkman P, Wagener AH, Riley JH, Sousa AR, Bates S, Wagers SS, De Meulder B, Auffray C, Wheelock ÅM, Bansal AT, Caruso M, Chanez P, Uddin M, Corfield J, Horvath I, Krug N, Musial J, Sun K, Shaw DE, Sandström T, Montuschi P, Fowler SJ, Lutter R, Djukanovic R, Howarth P, Skipp P, Sanak M, Adcock IM, Chung KF, Sterk PJ, Kraneveld AD, Maitland-van der Zee PharmD AH; U-BIOPRED Study Group. A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes. Eur Respir J. 2022 Jan 13;59(1):2102603. doi: 10.1183/13993003.02603-2021. PMID: 34824056.

33. Reinke SN, Naz S, Chaleckis R, Gallart-Ayala H, Kolmert J, Kermani NZ, Tiotiu A, Broadhurst DI, Lundqvist A, Olsson H, Ström M, Wheelock ÅM, Gómez C, Ericsson M, Sousa AR, Riley JH, Bates S, Scholfield J, Loza M, Baribaud F, Bakke PS, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Behndig A, Singer F, Musial J, Shaw DE, Dahlén B, Hu S, Lasky-Su J, Sterk PJ, Chung KF, Djukanovic R, Dahlén SE, Adcock IM, Wheelock CE; U-BIOPRED Study Group#. Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study. Eur Respir J. 2021 Nov 25:2101733. doi: 10.1183/13993003.01733-2021. Epub ahead of print. PMID: 34824054.

34. Mikus MS, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Khoonsari PE, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Niżankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlen M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A; U–BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium. Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation. Eur Respir J. 2021 Nov 4:2100142. doi: 10.1183/13993003.00142-2021. PMID: 34737220.

35. Caruso M, Emma R, Rust S, Distefano A, Carota G, Pulvirenti R, Polosa R, Li Volti G. Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes. Regul Toxicol Pharmacol. 2021 Oct;125:105018. doi: 10.1016/j.yrtph.2021.105018. Epub 2021 Jul 24. PMID: 34314750.

36. Polosa R, Emma R, Cibella F, Caruso M, Conte G, Benfatto F, Ferlito S, Gulino A, Malerba M, Caponnetto P. Impact of exclusive e-cigarettes and heated tobacco products use on muco-ciliary clearance. Ther Adv Chronic Dis. 2021 Aug 12;12:20406223211035267. doi: 10.1177/20406223211035267. PMID: 34422253; PMCID: PMC8371723.

37. Caruso M, Distefano A, Emma R, Di Rosa M, Carota G, Rust S, Polosa R, Zuccarello P, Ferrante M, Raciti G, Li Volti G. Role of Cigarette Smoke on Angiotensin-Converting Enzyme-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface Model. Front Pharmacol. 2021 Mar 30;12:652102. doi: 10.3389/fphar.2021.652102. PMID: 33859566; PMCID: PMC8042260.

38. Badi YE, Pavel AB, Pavlidis S, Riley JH, Bates S, Kermani NZ, Knowles R, Kolmert J, Wheelock CE, Worsley S, Uddin M, Alving K, Bakke PS, Behndig A, Caruso M, Chanez P, Fleming LJ, Fowler SJ, Frey U, Howarth P, Horváth I, Krug N, Maitland-van der Zee AH, Montuschi P, Roberts G, Sanak M, Shaw DE, Singer F, Sterk PJ, Djukanovic R, Dahlen SE, Guo YK, Chung KF, Guttman-Yassky E, Adcock IM; U-BIOPRED Study Group. Mapping atopic dermatitis and anti-IL-22 response signatures to type 2-low severe neutrophilic asthma. (2022) Journal of Allergy and Clinical Immunology, 149 (1), pp. 89-101. DOI: 10.1016/j.jaci.2021.04.010 

39. Zuccarello P, Rust S, Caruso M*, Emma R, Pulvirenti R, Favara C, Polosa R, Li Volti G, Ferrante M. Nicotine dosimetry and stability in cambridge filter PADs (CFPs) following different smoking regime protocols and storage conditions. Regul Toxicol Pharmacol. 2021 Jun;122:104917. doi: 10.1016/j.yrtph.2021.104917. Epub 2021 Mar 18. PMID: 33744373. *Corresponding author

40. O'Leary R, Polosa R, Li Volti G; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR)*. Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes. Harm Reduct J. 2021 Mar 10;18(1):31. doi: 10.1186/s12954-021-00476-6. PMID: 33691708; PMCID: PMC7945356. *part of the CoEHAR Center.

41. Alahmadi FH, Simpson AJ, Gomez C, Ericsson M, Thörngren JO, Wheelock C, Shaw DE, Fleming LJ, Roberts G, Riley J, Bates S, Sousa AR, Knowles R, Bansal AT, Corfield J, Pandis I, Sun K, Bakke PS, Caruso M, Chanez P, Dahlén B, Horvath I, Krug N, Montuschi P, Singer F, Wagers S, Adcock IM, Djukanovic R, Chung KF, Sterk PJ, Dahlen SE, Fowler SJ; U-BIOPRED Study Group. Medication Adherence in Patients with Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest. 2021 Feb 19:S0012-3692(21)00288-9. doi: 10.1016/j.chest.2021.02.023. Epub ahead of print. PMID: 33610577.

42. Kermani NZ, Song WJ, Badi Y, Versi A, Guo Y, Sun K, Bhavsar P, Howarth P, Dahlen SE, Sterk PJ, Djukanovic R, Adcock IM, Chung KF; U-BIOPRED Consortium: Uruj Hoda, Christos Rossios, Elisabeth Bel, Navin Rao, David Myles, Chris Compton, Marleen Van Geest, Peter Howarth, Graham Roberts, Diane Lefaudeux, Bertrand De Meulder, Aruna T Bansal, Richard Knowles, Damijn Erzen, Scott Wagers, Norbert Krug, Tim Higenbottam, John Matthews, Veit Erpenbeek, Leon Carayannopoulos, Amanda Roberts, David Supple, Pim de Boer, Massimo Caruso, Pascal Chanez, Sven-Erik Dahlen, Ildikó Horváth, Nobert Krug, Jacek Musial, Thomas Sandström. Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma. Respir Res. 2021 Jan 7;22(1):10. doi: 10.1186/s12931-020-01605-8. Erratum in: Respir Res. 2021 Feb 8;22(1):47. PMID: 33413387; PMCID: PMC7788167. (Correction in Respir Res. 22(1),47)

43. Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, Ericsson M, Thörngren JO, James A, Mikus M, Sousa AR, Riley JH, Bates S, Bakke PS, Pandis I, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Sanak M, Behndig A, Shaw DE, Knowles RG, Holweg CTJ, Wheelock ÅM, Dahlén B, Nordlund B, Alving K, Hedlin G, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Dahlén SE, Wheelock CE; U-BIOPRED Study Group, on behalf of the U-BIOPRED Study Group. Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study. Am J Respir Crit Care Med. 2021 Jan 1;203(1):37-53. doi: 10.1164/rccm.201909-1869OC. PMID: 32667261; PMCID: PMC7781128.

44. Corona D, Ekser B, Gioco R, Caruso M, Schipa C, Veroux P, Giaquinta A, Granata A, Veroux M. Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy? Biomolecules. 2020 May 30;10(6):840. doi: 10.3390/biom10060840. PMID: 32486245; PMCID: PMC7355572.

45. Caruso M, Fabroni S, Emma R, et al. A new standardized phytoextract from red orange and lemon wastes (red orange and lemon extract) reduces basophil degranulation and activation [published online ahead of print, 2020 May 6]. Nat Prod Res. 2020;1-6. doi:10.1080/14786419.2020.1761355

46. Li Volti G, Caruso M, Polosa R. Smoking and SARS-CoV-2 Disease (COVID-19): Dangerous Liaisons or Confusing Relationships? J Clin Med. 2020;9(5):1321. Published 2020 May 2. doi:10.3390/jcm9051321

47. Castracani CC, Longhitano L, Distefano A, Di Rosa M, Pittalà V, Lupo G, Caruso M, Corona D, Tibullo D, Li Volti G. Heme Oxygenase-1 and Carbon Monoxide Regulate Growth and Progression in Glioblastoma Cells. Mol Neurobiol. 2020 Feb 27. doi: 10.1007/s12035-020-01869-7. PubMed PMID: 32108290.

48. Castracani CC, Longhitano L, Distefano A, Anfuso D, Kalampoka S, La Spina E, Astuto M, Avola R, Caruso M, Nicolosi D, Giallongo C, Tibullo D, Volti GL. Role of 17β-Estradiol on Cell Proliferation and Mitochondrial Fitness in Glioblastoma Cells. J Oncol. 2020 Feb 14;2020:2314693. doi: 10.1155/2020/2314693. eCollection 2020. PubMed PMID: 32148493; PubMed Central PMCID: PMC7042539. 

49. Caponnetto P, Caruso M, Maglia M, Emma R, Saitta D, Busà B, Polosa R, Prosperini U, Pennisi A, Benfatto F, Sartorio C, Guastella M, Mondati E. Non-inferiority trial comparing cigarette consumption, adoption rates, acceptability, tolerability, and tobacco harm reduction potential in smokers switching to Heated Tobacco Products or electronic cigarettes: Study protocol for a randomized controlled trial. Contemp Clin Trials Commun. 2020 Jan 8;17:100518. doi: 10.1016/j.conctc.2020.100518. eCollection 2020 Mar. PubMed PMID: 31956726; PubMed Central PMCID: PMC6962654.

50. Cruz AA, Riley JH, Bansal AT, Ponte EV, Souza-Machado A, Almeida PCA, Biao-Lima V, Davis M, Bates S, Adcock IM, Sterk PJ, Chung KF; ProAR Study Group; U-BIOPRED Study Groups. Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status. Respir Med. 2019 Nov 26;161:105817. doi: 10.1016/j.rmed.2019.105817. *Part of the U-BIOPRED Consortium

51. Emma R, Polosa R, Caruso M*. High nicotine exposure in rodents is unlikely to inform about its toxicity in humans. Eur Respir J. 2019 Aug 29;54(2). pii:1801073. doi: 10.1183/13993003.01073-2018. Print 2019 Aug. PubMed PMID: 31467183. *Corresponding author

52. Polosa R, O'Leary R, Tashkin D, Emma R, Caruso M. The effect of e-cigarette aerosol emissions on respiratory health: a narrative review. Expert Rev Respir Med. 2019 Sep;13(9):899-915. doi: 10.1080/17476348.2019.1649146. Epub 2019 Aug PubMed PMID: 31375047.

1. Östling J., van Geest M., Schofield J.P.R., Jevnikar Z., Wilson S., Ward J., Lutter R., Shaw D.E., Bakke P.S., Caruso M., Dahlen S.-E., Fowler S.J., Horváth I., Krug N., Montuschi P., Sanak M., Sandström T., Sun K., Pandis I., Auffray C., Sousa A.R., Guo Y., Adcock I.M., Howarth P., Chung K.F., Bigler J., Sterk P.J., Skipp P.J., Djukanović R., Vaarala, O., Adcock I.M., Ahmed, H. IL-17–high asthma with features of a psoriasis immunophenotype. Journal of Allergy and Clinical Immunology. Volume 144, Issue 5, November 2019, Pages 1198-1213

54. Mathieu Césaire, Utpal Ghosha, Jean-Baptiste Austry, Etienne Mullere, Francesco Paolo Cammarata, Marilyne Guillamini, Massimo Caruso, Laurent Castérae, Giada Petringa, Giuseppe Antonio Pablo Cirrone, François Chevalier. Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation. Journal of Bone Oncology 17 (2019) 100246 https://doi.org/10.1016/j.jbo.2019.100246

55. JM, Schofield JPR, Wilson SJ, Ward J, Brandsma J, Strazzeri F, Bansal A, Yang X, Rowe A, Corfield J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlén B, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, De Meulder B, Lefaudeux D, Riley JH, Perotin Sousa AR, Dahlen SE, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Collins JE, Davies DE, Djukanović R; U-BIOPRED Study Group. Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux. Eur Respir J. 2019 Jun 27;53(6). pii:1900453. doi: 10.1183/13993003.00453-2019. Print 2019 Jun. PubMed PMID: 31023846.

56. Tariq K, Schofield JPR, Nicholas BL, Burg D, Brandsma J, Bansal AT, Wilson SJ, Lutter R, Fowler SJ, Bakke, Caruso M, Dahlen B, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Geiser T, Pandis I, Sousa AR, Adcock IM, Shaw DE, Auffray C, Howarth PH, Sterk PJ, Chung KF, Skipp PJ, Dimitrov B, Djukanović R; U-BIOPRED Study Group. Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma. Respir Med. 2019 Apr;150:66-73. doi:10.1016/j.rmed.2019.02.008.

57. Schofield JPR, Burg D, Nicholas B, Strazzeri F, Brandsma J, Staykova D, Folisi C, Bansal AT, Xian Y, Guo Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Riley J, Auffray C, De Meulder B, Lefaudeux D, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Djukanović R; U-BIOPRED Study Group. Stratification of asthma phenotypes by airway proteomic signatures. J Allergy Clin Immunol. 2019 Mar 28. pii:S0091-6749(19)30415-4. doi: 10.1016/j.jaci.2019.03.013. 

58. Morjaria JB, Emma R, Fuochi V, Polosa R, Caruso M*. An evaluation of mepolizumab for the treatment of severe asthma. Expert Opin Biol Ther. 2019 Jun;19(6):491-500. doi: 10.1080/14712598.2019.1610382. *Corresponding author

59. Emma R, Morjaria JB, Fuochi V, Polosa R, Caruso M*. Mepolizumab in the management of severe eosinophilic asthma in adults: current evidence and practical experience. Ther Adv Respir Dis. 2018 Jan-Dec;12:1753466618808490. doi: 10.1177/1753466618808490.

60. Brinkman P, Wagener AH, Hekking PP, Bansal AT, Maitland-van der Zee AH, Wang Y, Weda H, Knobel HH, Vink TJ, Rattray NJ, D'Amico A, Pennazza G, Santonico M, Lefaudeux D, De Meulder B, Auffray C, Bakke PS, Caruso M, Chanez P, Chung KF, Corfield J, Dahlén SE, Djukanovic R, Geiser T, Horvath I, Krug N, Musial J, Sun K, Riley JH, Shaw DE, Sandström T, Sousa AR, Montuschi P, Fowler SJ, Sterk PJ; U-BIOPRED Study Group. Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma. J Allergy Clin Immunol. 2018 Dec 6. pii: S0091-6749(18)31722-6. doi: 10.1016/j.jaci.2018.10.058. PubMed PMID: 30529449.

61. Simpson AJ, Hekking PP, Shaw DE, Fleming LJ, Roberts G, Riley JH, Bates S, Sousa AR, Bansal AT, Pandis I, Sun K, Bakke PS, Caruso M, Dahlén B, Dahlén SE, Horvath I, Krug N, Montuschi P, Sandstrom T, Singer F, Adcock IM, Wagers SS, Djukanovic R, Chung KF, Sterk PJ, Fowler SJ; U-BIOPRED Study Group. Treatable traits in the European U-BIOPRED adult asthma cohorts. Allergy. 2018 Oct 11. doi: 10.1111/all.13629. PubMed PMID: 30307629.

62. Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M*; U-BIOPRED Study Group. Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort. PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018. PubMed PMID: 30240401. *Corresponding author

63. Brandsma J, Goss VM, Yang X, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Sousa AR, Pandis I, Bansal AT, Sterk PJ, Djukanović R, Postle AD; U-BIOPRED Study Group. Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers. Metabolomics. 2018 Sep 17;14(10):123. doi:10.1007/s11306-018-1412-2.

64. Polosa R, Morjaria JB, Prosperini U, Russo C, Pennisi A, Puleo R, Caruso M, Caponnetto P. Health effects in COPD smokers who switch to electronic cigarettes: a retrospective-prospective 3-year follow-up. Int J Chron Obstruct Pulmon Dis. 2018 Aug 22;13:2533-2542. doi: 10.2147/COPD.S161138. eCollection 2018. PubMed PMID: 30197510; PubMed Central PMCID: PMC6113943.

65. Caruso M, Li Volti G, Furneri PM, Fuochi V, Emma R, Polosa R. Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine. Frontiers in Physiology. 2018 Sep 13;9:1240. doi: 10.3389/fphys.2018.01240. eCollection 2018. PubMed PMID: 30271350; PubMed Central PMCID: PMC6147174.

66. Caruso M*, Emma R, Fuochi V, Furneri PM, Polosa R. Electronic cigarette vapour enhances pneumococcal adherence to airway epithelial cells under abnormal conditions of exposure. Eur Respir J. 2018 Sep 6;52(3). pii: 1800915. doi:10.1183/13993003.00915-2018. Print 2018 Sep. PubMed PMID: 30190260. *Corresponding author

67. Caruso M*, Cibella F, Emma R, Campagna D, Tringali G, Amaradio MD, Polosa R. Basophil biomarkers as useful predictors for sublingual immunotherapy in allergic rhinitis. Int. Immunopharmacol. 2018 Jul; 60:50-58. doi: 10.1016/j.intimp.2018.04.034. Epub 2018 Apr 25. PubMed PMID: 29702283. *Corresponding author

68. Burg D, Schofield JPR, Brandsma J, Staykova D, Folisi C, Bansal A, Nicholas B, Xian Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Fleming L, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Hashimoto S, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Singer F, Sun K, Pandis I, Auffray C, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Djukanović R, Skipp PJ, The U-Biopred Study Group. Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome. J Proteome Res. 2018 Jun 1;17(6):2072-2091. doi: 10.1021/acs.jproteome.8b00018. Epub 2018 May 23. PubMed PMID: 29737851.

69. Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau LCK, Wilson SJ, Ward JA, Chauhan A, Sousa AR, De Meulder B, Loza MJ, Baribaud F, Sterk PJ, Chung KF, Sun K, Guo Y, Adcock IM, Payne D, Dahlen B, Chanez P, Shaw DE, Krug N, Hohlfeld JM, Sandström T, Djukanovic R, James A, Hinks TSC, Howarth PH, Vaarala O, van Geest M, Olsson H; Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group. Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation. J Allergy Clin Immunol. 2019 Feb;143(2):577-590. doi:10.1016/j.jaci.2018.05.026. Epub 2018 Jun 11. PubMed PMID: 29902480.

70. Morjaria JB*, Caruso M*, Emma R, Russo C, Polosa R. Treatment of Allergic Rhinitis as a Strategy for Preventing Asthma. Curr Allergy Asthma Rep. 2018 Mar 24;18(4):23. doi: 10.1007/s11882-018-0781-y. PubMed PMID: 29574527. *Co-first author

71. Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Dahlen SE, Krug N, Sandstrom T, Shaw DE, Lutter R, Bakke P, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; on behalf of the U-BIOPRED study group. Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis. Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017. Print 2018 May. PubMed PMID: 29650557.

72. Russo C, Cibella F, Mondati E, Caponnetto P, Frazzetto E, Caruso M, Caci G, Polosa R. Lack of Substantial Post-Cessation Weight Increase in Electronic Cigarettes Users. Int J Environ Res Public Health. 2018 Mar 23;15(4). pii: E581. doi: 10.3390/ijerph15040581. PubMed PMID: 29570695; PubMed Central PMCID:PMC5923623.

73.  Li Volti G, Polosa R, Caruso M*. Assessment of E-cigarette impact on smokers: the importance of experimental conditions relevant to human consumption. Proc Natl Acad Sci USA. 2018 Apr 3;115(14):E3073-E3074. doi:10.1073/pnas.1801967115. PubMed PMID: 29535226; PubMed Central PMCID: PMC5889678.

74. Caruso M, Morjaria J, Emma R, Amaradio MD, Polosa R. Biologic agents for severe asthma patients: clinical perspectives and implications. Intern Emerg Med. 2018 Mar;13(2):155-176. doi: 10.1007/s11739-017-1773-y. PubMed PMID: 29238905. 

75. Di Mauro MD, Tomasello B, Giardina RC, Dattilo S, Mazzei V, Sinatra F, Caruso M, D'Antona N, Renis M. Sugar and mineral enriched fraction from olive mill wastewater for promising cosmeceutical application: characterization, in vitro and in vivo studies. Food Funct. 2017 Dec 13;8(12):4713-4722. doi:10.1039/c7fo01363a. PubMed PMID: 29165474.

76. Caruso M, Polosa R. Perplexing Conclusions Concerning Heat-Not-Burn Tobacco Cigarettes. JAMA Intern Med. 2017 Nov 1;177(11):1699. doi: 10.1001/jamainternmed.2017.5843. PubMed PMID: 29114793.

77. Takahashi K, Pavlidis S, Kwong FNK, Hoda U, Rossios C, Sun K, Loza MJ, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Sanak M, Dahlen B, Krug N, Sandström T, Shaw D, Lutter R, Fleming L, Howarth P, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF. Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis. Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017.

78. M. Caruso, R. Emma, P. Brinkman, P.J. Sterk, A.T. Bansal, B. De Meulder, D. Lefaudeux, C. Auffray, S.J. Fowler, N.J.W. Rattray, G. Pennazza, P. Bakke, P. Chanez, I. Horvath, N. Krug, P. Montuschi, M. Sanak, T. Sandström, D. Shaw, K.F. Chung, R. Djukanovic, F. Singer, A.R. Sousa, S.E. Dahlén, J. Kolmert, H. Weda, A. Vink, H. Knobel. Volatile Organic Compounds Breathprinting of U-BIOPRED Severe Asthma smokers/ex-smokers cohort. Eur Respir J. September 2017. Doi:10.1183/1393003.congress-2017.PA2018. Conference: ERS 2017. 

79. Craig E Wheelock, Shama Naz, Stacey Reinke, Romanas Chaleckis, James Schofield, Paul Skipp, Jeanette Bigler, Matthew J Loza, Fred Baribaud, Per Bakke, Massimo Caruso, Pascal Chanez, Stephen J Fowler, Kiss Horvath, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Dominick Shaw, Fan Chung, Ratko Djukanovic, Florian Singer, Ana Sousa, Ioannis Pandis, Aruna T Bansal, Peter Sterk, Sven-Erik Dalhén. Urinary metabolomics-based molecular sub-phenotyping of the U-BIOPRED asthma cohort. Eur Respir J. September 2017 Doi:10.1183/1393003.congress-2017.PA4939. Conference: ERS International Congress 2017 abstracts. 

80. Hekking PP, Loza MJ, Pavlidis S, de Meulder B, Lefaudeux D, Baribaud F, Auffray C, Wagener AH, Brinkman P Ir, Lutter R Ir, Bansal AT, Sousa AR, Bates SA, Pandis Y, Fleming LJ, Shaw DE, Fowler SJ, Guo Y, Meiser A, Sun K, Corfield J, Howarth PH, Bel EH, Adcock IM, Chung KF, Djukanovic R, Sterk PJ; U-BIOPRED Study Group. Pathway discovery using transcriptomic profiles in adult-onset severe asthma. J Allergy Clin Immunol. 2018 Apr;141(4):1280-1290. doi:10.1016/j.jaci.2017.06.037. PubMed PMID: 28756296.

81. Dominick E. Shaw, Ana R. Sousa, Stephen J. Fowler, Louise  J. Fleming, Graham Roberts, Julie Corfield, Ioannis Pandis, Aruna T. Bansal, Elisabeth H. Bel, Charles Auffray, Chris H. Compton, Hans Bisgaard, Enrica Bucchioni, Massimo Caruso, Pascal Chanez, Barbro Dahlén, Sven-Erik Dahlen, Kerry  Dyson, Urs Frey, Thomas Geiser, Maria Gerhardsson de Verdier, David Gibeon, Yi-ke Guo, Simone Hashimoto, Gunilla Hedlin, Elizabeth Jeyasingham, Pieter-Paul W. Hekking, Tim Higenbottam, Ildikó Horváth, Alan J. Knox, Norbert Krug, Veit J. Erpenbeck, Lars X. Larsson, Nikos Lazarinis, John G. Matthews, Roelinde Middelveld, Paolo Montuschi, Jacek Musial, David Myles, Laurie Pahus, Thomas Sandström, Wolfgang Seibold, Florian Singer, Karin Strandberg, Jorgen Vestbo, Nadja Vissing, Christophe von Garnier, Ian M. Adcock, Scott Wagers, Anthony Rowe, Peter Howarth, Ariane H. Wagener, Ratko Djukanovic, Peter J. Sterk and Kian Fan Chung on behalf of the U-BIOPRED Study Group. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J 2015; 46: 1308-1321. Eur Respir J. 2017 Jun 22;49(6). pii: 1550779. doi: 10.1183/13993003.50779-2015.  Print 2017 Jun. PubMed PMID: 28642304.

82. Loza MJ, Djukanovic R, Chung KF, et al. ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators.; Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study. Respir Res. 2016 Dec 15;17(1):165. PubMed PMID: 27978840.

83. Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group. U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics. J Allergy Clin Immunol. 2017;139(6):1797–1807. doi:10.1016/j.jaci.2016.08.048 PubMed PMID: 27773852.

84. Cibella F, Campagna D, Caponnetto P, Amaradio MD, Caruso M, Russo C, Cockcroft DW, Polosa R. Lung function and respiratory symptoms in a randomized smoking cessation trial of electronic cigarettes. Clin Sci (Lond). 2016 Nov 1;130(21):1929-37. doi: 10.1042/CS20160268. PubMed PMID:27543458.

85. Emma R, Caruso M, Polosa R. Smoking history can influence the epigenetic and gene expression profile. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L525. doi: 10.1152/ajplung.00285.2016. PubMed PMID: 27507815.

86. Campagna D, Cibella F, Caponnetto P, Amaradio MD, Caruso M, Morjaria JB, Malerba M, Polosa R. Changes in breathomics from a 1-year randomized smoking cessation trial of electronic cigarettes. Eur J Clin Invest. 2016 Jun 20. doi: 10.1111/eci.12651.

87. Polosa R, Morjaria JB, Caponnetto P, Caruso M, Campagna D, Amaradio MD, Ciampi G, Russo C, Fisichella A. Persisting long-term benefits of smoking abstinence and reduction in asthmatic smokers who have switched to electronic cigarettes. Discov Med. 2016 Feb;21(114):99-108.

1. Russo C, Cibella F, Caponnetto P, Campagna D, Maglia M, Frazzetto E, Mondati E, Caruso M, Polosa R. Evaluation of Post Cessation Weight Gain in a 1-Year Randomized Smoking Cessation Trial of Electronic Cigarettes. Sci Rep. 2016 Jan 5;6:18763. doi: 10.1038/srep18763. PubMed PMID: 26729619; PubMed Central PMCID: PMC4700433.
2. K Farsalinos, F Cibella, P Caponnetto, D Campagna, JB Morjaria, E Battaglia, M Caruso, C Russo, R Polosa. Effect of continuous smoking reduction and abstinence on blood pressure and heart rate in smokers switching to electronic cigarettes. Intern Emerg Med. 2016 Feb;11(1):85-94. doi: 10.1007/s11739-015-1361-y. PubMed PMID: 26749533.

90. Polosa R, Caruso M, Guarino F. Comments on Scheffler et al. Cytotoxic Evaluation of E-Liquid Aerosol using Different Lung Derived Cell Models. Int J Environ Res Public Health. 2016 Jan 6;13(1). pii: E108. doi: 10.3390/ijerph13010108. PubMed PMID: 26751462; PubMed Central PMCID: PMC4730499.

91. Marino E, Caruso M, Campagna D, Polosa R. Impact of air quality on lung health: myth or reality? Ther Adv Chronic Dis. 2015 Sep;6(5):286-98. doi: 10.1177/2040622315587256. Review. PubMed PMID: 26336597; PubMed Central PMCID: PMC4549691.

1. Polosa R, Caruso M, Caponnetto P. Acrolein levels in e-cigarettes - Letter. Cancer Prev Res (Phila). 2015 Nov 10. PubMed PMID: 26554633.
2. Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, Pandis I, Bansal AT, Bel EH, Auffray C, Compton CH, Bisgaard H, Bucchioni E, Caruso M, et al.; Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. U-BIOPRED Study Group. Eur Respir J. 2015 Nov;46(5):1308-21. doi: 10.1183/13993003.00779-2015.
3. Bonaventura G, Chamayou S, Liprino A, Guglielmino A, Fichera M, Caruso M, Barcellona ML. Different Tissue-Derived Stem Cells: A Comparison of Neural Differentiation Capability. PLoS One. 2015 Oct 30;10(10):e0140790. doi:10.1371/journal.pone.0140790. eCollection 2015.
4. Polosa R, Bellinvia S, Caruso M, Emma R, Alamo A, Kowalski ML, Domingo C. Weekly low-dose methotrexate for reduction of Global Initiative for Asthma Step 5 treatment in severe refractory asthma: study protocol for a randomized controlled trial. Trials. 2014 Dec 18;15:492. doi: 10.1186/1745-6215-15-492.
5. Luca T, Barresi V, Privitera G, Musso N, Caruso M, Condorelli DF, Castorina S. In vitro combined treatment with cetuximab and trastuzumab inhibits growth of colon cancer cells. Cell Prolif. 2014 Oct;47(5):435-447.
6. Polosa R, Morjaria J, Caponnetto P, Caruso M, Strano S, Battaglia E, Russo C. Effect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversal. Int J Environ Res Public Health. 2014 May 8;11(5):4965-77. doi: 10.3390/ijerph110504965.

98. Morjaria JB, Caruso M, Rosalia E, Russo C, Polosa R. Preventing progression of allergic rhinitis to asthma. Curr Allergy Asthma Rep. 2014 Feb;14(2):412. doi:10.1007/s11882-013-0412-6. Review. PubMed PMID: 24408536.

1. Polosa R, Caruso M, Oliveri Conti G, Ferrante M. Air Pollution: focus on lung health. Intern Emerg Med (2013) 8 (Suppl): S47–S54.
2. Caruso M, Crisafulli E, Lizzio R, Polosa R. Biologic therapy for atopic asthma and beyond.  Curr Opin Allergy Clin Immunol. 2013 Dec;13(6):677-85.
3. Caponnetto P, Campagna D, Cibella F, Morjaria JB, Caruso M, Russo C, Polosa R. EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study. PLoS One. 2013 Jun 24;8(6):e66317
4. Spicuzza L, Scuderi V, Morjaria JB, Prosperini G, Arcidiacono G, Caruso M, Folisi C, Di Maria GU, Polosa R. Airway responsiveness to adenosine after a single dose of fluticasone propionate discriminates asthma from COPD. Pulm Pharmacol Ther. 2013 May 18.
5. Caruso M*, Alamo A, Crisafulli E, Raciti C, Fisichella A, Polosa R. Adenosine signaling pathways as potential therapeutic targets in respiratory disease. Expert Opin Ther Targets. 2013 May 4.
6. Caruso M*, Crisafulli E, Demma S, Holgate S, Polosa R. Disabling inflammatory pathways with biologics and resulting clinical outcomes in severe asthma. Expert Opin Biol Ther. 2013 Mar;13(3):393-402.
7. Guarino F, Cantarella G, Caruso M, Russo C, Mancuso S, Arcidiacono G, Cacciola RR, Bernardini R, Polosa R. Endothelial activation and injury by cigarette smoke exposure. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):259.
8. Li Volti G, Galvano F, Frigiola A, Guccione S, Di Giacomo C, Forte S, Tringali G, Caruso M, Adekoya OA, Gazzolo D. Potential immunoregulatory role of heme oxygenase-1 in human milk: a combined biochemical and molecular modeling approach. J Nutr Biochem. 2010 Sep;21(9):865-71.
9. Caruso M, Varani K, Tringali G, Polosa R. Adenosine and adenosine receptors: their contribution to airway inflammation and therapeutic potential in asthma. Curr Med Chem. 2009;16(29):3875-85. Review. PubMed PMID: 19747135.
10. Caruso M, Frasca G, Di Giuseppe PLM, Pennisi A, Tringali G, Bonina FP. Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects. International Immunopharmacology. 2008 Dec 20;8(13-14):1781-6. 
11. Li Volti G, Sorrenti V, Acquaviva R, Murabito P, Gullo A, Barcellona ML, Galvano F, Rodella L, Rezzani R, Vanella L, Tringali G, Caruso M, Gazzolo D, Di Giacomo C. Effect of ischemia/reperfusion on renal expression and activity of NG-NG-dimethylarginine dimethylaminohydrolases. Anesthesiology. 2008 Dec;109(6):1054-62.
12. Caruso M, Tringali G, Di Giuseppe PLM, Pennisi AR, Roccaro G, Polosa R. Diagnoses of adverse drug reactions by flow cytometry basophils degranulation test vs basophils activation test. Proceedings of the XXV National Conference of the Italian Society GIC. Cytometry (Part A). 2007 Dec. 73A (1); 48–108.
13. Caruso M, Tringali G, Polosa R.  Evidence for A Functional Contribution of Adenosine Signalling in Inflammatory Airway Diseases. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2007 August, Volume 7, No. 4. pp. 286-297.
14. Caruso M, Holgate ST, Polosa R. Adenosine signalling in airways. Curr Opin Pharmacol. 2006 Jun;6(3):251-6. Epub 2006 Apr 3.
15. C Di Pietro, S Piro, G Tabbì, M Ragusa,V Di Pietro, V Zimmitti, M Anello, U Consoli, E Trovato Salinaro, M Caruso, C Vancheri, N Crimi, MG Sabini, GAP Cirrone, L Raffaele, G Privitera, A Pulvirenti, R Giugno, A Ferro, G Cuttone, S Lo Nigro, R Purrello, F Purrello, M Purrello. Cellular and Molecular Effects Of Protons: Apoptosis Induction And Potential Implications For Cancer Therapy. Apoptosis. 2006 Jan;11(1):57-66.

114. Vancheri C, Gili E, Mastruzzo C, Trovato Salinaro E, LoFurno D, Pistorio MP, Caruso M, La Rosa C, Failla M, Crimi N. Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 receptor. J Allergy Clin Immunol. 2005 Dec;116(6):1242-8. 

115. Vancheri C, Mastruzzo C, Trovato-Salinaro E, Gili E, Lo Furno D, Pistorio MP, Caruso M, La Rosa C, Crimi C, Failla M, Crimi N. Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells. Respir Res. 2005 Sep 13;6:103.

116. Calafiore M., Battaglia G., Zappalà A., Trovato-Salinaro E., Caraci F., Caruso M., Vancheri C., Sortino M.A., Nicoletti F., and Copani A. Progenitor cells form the adult mouse brain acquire a neuronal phenotype in response to ß-amyloid. Neurobiol Aging. 2006 Apr; 27(4):606-13.

117. Sortino M.A., Chiari M., Vancheri C., Caruso M., Nicoletti F., Canonico P.L., Copani A. Glia Mediates the Neuroprotective Action of Estradiol on beta-Amiloid-Induced Neuronal Death. Endocrinology 2004 Nov; 145(11): 5080-6. 

• Citotossicità indotta dal fumo di sigaretta
• Citotossicità indotta dal vapore dei dispositivi elettronici “no-burn” alternativi alla sigaretta classica
• Biomarcatori di attivazione dei Basofili nella reazione allergica classica (Tipo I)
• Fenotipizzazione molecolare dell’asma allergica, asma grave ed asma nei soggetti fumatori
• Novel Alternative Metodologies (NAMs)